Approximately 3 hours/150 miles. Take NYS Thruway (I-90) east to Exit 41; then take Route 318 east to Route 89 south into Ithaca.
Approximately 6 hours/330 miles. Take the Mass. Turnpike (I-90) west to I-88W. At Bainbridge take Route 206 west to Whitney Point; then take Route 79 into Ithaca.
Approximately 4 hours/230 miles. Take I-276 west to the Northeast Extension or Route 9 north to I-81 north to Exit 8; then follow Route 79 into Ithaca.
From New York Metro Area:
Approximately 4 hours/240 miles. Take I-80 west to I-380 west, then I-81 north to Exit 8; then Route 79 west into Ithaca. Or take the Palisades Parkway north to Route 6 west to Route 17 west; then take Route I-81 north to Exit 8; then follow Route 79 into Ithaca.